What is a charged aerosol detector (CAD)?

The Charged Aerosol Detector (CAD) is a detector used in conjunction with high-performance liquid chromatography (HPLC) and ultra high-performance liquid chromatography (UHPLC) to measure the amount of chemicals in a sample by creating charged aerosol particles which are detected using an electrometer.

What is a CAD detector?

The CAD, like other aerosol detectors (e.g., evaporative light scattering detectors (ELSD) and condensation nucleation light scattering detectors (CNLSD)), falls under the category of destructive general-purpose detectors (see Chromatography Detectors ).

What types of analytes can a CAD measure?

The CAD can measure all non-volatile and many semi-volatile analytes including, but not limited to, antibiotics, excipients, ions, lipids, natural products, biofuels, sugars and surfactants.

Why is CAD used in research & development?

CAD has shown great success in research and development (R&D) laboratories where it has proven its reliability, ease of use, wide dynamic range, less inter-analyte response variability, and applicability to wide range of analytes [ 3, 4, 16 ].